$84.00

APIDRA

It is best to use a different place on the body for each injection (e.g., abdomen, thigh, or upper arm). If you have questions about this, contact a member of your health care team.

When used as a mealtime insulin, insulin glulisine should be taken within 15 minutes before the meal or within 20 minutes after starting a meal.

Follow carefully the special meal plan your doctor gave you. This is the most important part of controlling your condition, and is necessary if the medicine is to work properly. Also, exercise regularly and test for sugar in your blood or urine as directed.

The dose of insulin glulisine will be different for different patients. Follow your doctor's orders.

• For injection dosage form:
  • For diabetes mellitus (sugar diabetes):
    • Adults The dose is based on your blood sugar and must be determined by your doctor.
    • Children Use and dose must be determined by your doctor.

Storage

To store this medicine:

• Keep out of the reach of children.
• Store away from heat and direct light.
• Store in the refrigerator. However, keep the medicine from freezing.
• Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For insulin glulisine, the following should be considered:

Allergies Tell your doctor if you have ever had any unusual or allergic reaction to insulin glulisine. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy The amount of insulin or insulin glulisine you need changes during pregnancy. It is especially important for your health and your baby's health that your blood sugar be closely controlled before you become pregnant and throughout pregnancy.

Breast-feeding It is not known whether insulin glulisine passes into human breast milk. Although most medicines, including human insulin, pass into breast milk in small amounts, many of them may be used safely while breast-feeding. Mothers who are taking this medicine and who wish to breast-feed should discuss this with their doctor.

Children Studies on this medicine have been done only in adult patients, and there is no specific information comparing use of insulin glulisine in children with use in other age groups.

Older adults This medicine has been tested in a limited number of patients 65 years of age or older and has not been shown to cause different side effects or problems in older people than it does in younger adults.

Other medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking insulin glulisine, it is especially important that your doctor and pharmacist know if you are taking any of the following:

• Beta-adrenergic blocking agents (acebutolol [e.g., Sectral], atenolol [e.g., Tenormin], betaxolol [e.g., Kerlone], bisoprolol [e.g., Zebeta], carteolol [e.g., Cartrol], labetalol [e.g., Normodyne, Trandate], metoprolol [e.g., Lopressor], nadolol [e.g., Corgard], oxprenolol [e.g., Trasicor], penbutolol [e.g., Levatol], pindolol [e.g., Visken], propranolol [e.g., Inderal], sotalol [e.g., Betapace], timolol [e.g., Blocadren]) or
• Clonidine (e.g., Catapres, Duraclon) or
• Guanethidine (e.g., Ismelin) or
• Reserpine These medicines may hide symptoms of low blood sugar (such as fast heartbeat). Thus, a person with diabetes might not recognize that he or she has low blood sugar and might not take immediate steps to treat it

• Hypoglycemia (low blood sugar) If you have low blood sugar and take insulin, your blood sugar may reach dangerously low levels
• Kidney disease or

• Liver disease Effects of insulin glulisine may be increased or decreased; your doctor may need to change your insulin dose