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Medical Information
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Additional Information
Why is this medication prescribed
The combination of diclofenac and misoprostol is used to relieve the pain, tenderness, inflammation (swelling), and stiffness caused by osteoarthritis and rheumatoid arthritis in patients who have a high risk of developing stomach ulcers. Diclofenac is in a class of medications called nonsteroidal anti-inflammatory medications (NSAIDs). It works by stopping the body's production of a substance that causes pain and inflammation. Misoprostol is in a class of medications called prostaglandins. It prevents ulcers caused by diclofenac by protecting the stomach lining and decreasing stomach acid production.
Other uses for this medicine
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What other information should I know
Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your body's response to diclofenac and misoprostol.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
Warnings
| Do not take diclofenac and misoprostol if you are pregnant or plan to become pregnant. If you become pregnant while taking diclofenac and misoprostol, stop taking the medication and call your doctor immediately. Diclofenac and misoprostol causes miscarriages and serious bleeding if taken during pregnancy. If you are a woman of childbearing age you should not take this medication unless you need nonsteroidal anti-inflammatory (NSAID) therapy and you are at high risk for stomach ulcers. If you and your doctor decide you need this medication, you must: have a negative pregnancy blood test within 2 weeks before starting to take diclofenac and misoprostol;use a reliable method of birth control; and begin the medication only on the second or third day of the next normal menstrual period.Wait at least 1 month or through one menstrual cycle after you stop taking diclofenac and misoprostol before you try to become pregnant.Before taking diclofenac and misoprostol, carefully read the manufacturer's information for the patient that comes with it.Do not give this medication to anyone else, especially a woman who is or could become pregnant. |
In case of emergency overdose
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
Symptoms of overdose may include:
- stomach pain
- confusion
- drowsiness
- low muscle tone
- shaking hands that you cannot control
- seizures
- shortness of breath
- diarrhea
- fever
- rapid or pounding heartbeat
- slow heartbeat
- dizziness
- fainting


