$110.59

FLUANXOL DEPOT

(Also Known As: FLUPENTHIXOL DECANOATE)

This medicine may be taken with food or a full glass (8 ounces) of water or milk to reduce stomach irritation.

For patients taking thiothixene oral solution:

• This medicine must be diluted before you take it. Just before taking, measure the dose with the specially marked dropper. Mix the medicine with a full glass of water, milk, tomato or fruit juice, soup, or carbonated beverage.

Do not take more of this medicine or take it more often than your doctor ordered. This is particularly important when this medicine is given to children, since they may react very strongly to its effects.

Sometimes this medicine must be taken for several weeks before its full effect is reached.

Dosing

The dose of these medicines will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so.

The number of capsules or tablets or the amount of liquid that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are taking thioxanthenes.

For chlorprothixene
• For treatment of psychosis:
  • Oral dosage forms (suspension or tablets):
    • Adults and teenagers 25 to 50 milligrams (mg) three or four times a day.
    • Children 6 to 12 years of age 10 to 25 mg three or four times a day.
    • Children up to 6 years of age Use and dose must be determined by your doctor.
  • Injection dosage form:
    • Adults and teenagers 25 to 50 mg, injected into a muscle, three or four times a day.
    • Children up to 12 years of age Use and dose must be determined by your doctor.

For flupenthixol
• For treatment of psychosis:
  • Oral dosage form (tablets):
    • Adults To start, 1 milligram (mg) three times a day. Your doctor may increase your dose if needed, depending on your condition.
    • Children Use and dose must be determined by your doctor.
  • Long-acting injection dosage form:
    • Adults To start, 20 to 40 milligrams (mg) injected into a muscle. Your doctor will determine whether your dose needs to be changed, depending on your condition.
    • Children Use and dose must be determined by your doctor.

For thiothixene
• For treatment of psychosis:
  • Oral dosage forms (capsules and solution):
    • Adults and teenagers To start, 2 milligrams (mg) three times a day, or 5 mg two times a day. Your doctor may increase your dose if needed. However, the dose is usually not more than 60 mg a day.
    • Children up to 12 years of age Use and dose must be determined by your doctor.
  • Injection dosage form:
    • Adults and teenagers 4 milligrams (mg), injected into a muscle, two to four times a day. Your doctor may increase your dose if needed. However, the dose is usually not more than 30 mg a day.
    • Children up to 12 years of age Use and dose must be determined by your doctor.

Missed dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is within 2 hours of your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

To store this medicine:

• Keep out of the reach of children.
• Store away from heat and direct light.
• Do not store the capsule or tablet form of this medicine in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down.
• Keep the liquid form of this medicine from freezing.
• Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For thioxanthenes, the following should be considered:

Allergies Tell your doctor if you have ever had any unusual or allergic reaction to thioxanthene or to phenothiazine medicines. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy Studies have not been done in pregnant women. Although animal studies have not shown that thioxanthenes cause birth defects, the studies have shown that these medicines cause a decrease in fertility and fewer successful pregnancies.

Breast-feeding It is not known if thioxanthenes pass into the breast milk. However, similar medicines for nervous, mental, or emotional conditions do pass into breast milk and may cause drowsiness and increase the risk of other problems in the nursing baby. Be sure you have discussed the risks and benefits of this medicine with your doctor.

Children Certain side effects, such as muscle spasms of the face, neck, and back, tic-like or twitching movements, inability to move the eyes, twisting of the body, or weakness of the arms and legs, are more likely to occur in children, who are usually more sensitive than adults to the side effects of thioxanthenes.

Older adults Constipation, dizziness or fainting, drowsiness, dryness of mouth, trembling of the hands and fingers, and symptoms of tardive dyskinesia (such as rapid, worm-like movements of the tongue or any other uncontrolled movements of the mouth, tongue, or jaw, and/or arms and legs) are especially likely to occur in elderly patients, who are usually more sensitive than younger adults to the effects of thioxanthenes.

Other medicines Although certain medicines should not be used together at all, in other cases 2 different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking thioxanthenes, it is especially important that your health care professional know if you are taking any of the following:

• Amoxapine (e.g., Asendin) or
• Methyldopa (e.g., Aldomet) or
• Metoclopramide (e.g., Reglan) or
• Metyrosine (e.g., Demser) or
• Other antipsychotics (medicine for mental illness) or
• Pemoline (e.g., Cylert) or
• Pimozide (e.g., Orap) or
• Promethazine (e.g., Phenergan) or
• Rauwolfia alkaloids (alseroxylon [e.g., Rauwiloid], deserpidine [e.g., Harmonyl], rauwolfia serpentina [e.g., Raudixin], reserpine [e.g., Serpasil]) or
• Trimeprazine (e.g., Temaril) Taking these medicines with thioxanthenes may increase the chance and severity of certain side effects

• Central nervous system (CNS) depressants (medicine that causes drowsiness) or
• Tricyclic antidepressants (medicine for depression) Taking these medicines with thioxanthenes may add to the CNS depressant effects

• Epinephrine (e.g., Adrenalin) Severe low blood pressure (hypotension) and fast heartbeat may occur if epinephrine is used with thioxanthenes

• Levodopa (e.g., Sinemet) Thioxanthenes may keep levodopa from working properly in the treatment of Parkinson's disease

• Quinidine (e.g., Quinidex) Unwanted effects on your heart may occur

• Alcohol abuse Drinking alcohol will add to the central nervous system (CNS) depressant effects of thioxanthenes

• Blood disease or
• Enlarged prostate or
• Glaucoma or
• Heart or blood vessel disease or
• Lung disease or
• Parkinson's disease or
• Stomach ulcers or
• Urination problems Thioxanthenes may make the condition worse

• Liver disease Higher blood levels of thioxanthenes may occur, increasing the chance of side effects

• Reye's syndrome The risk of liver problems may be increased

• Seizure disorders The risk of seizures may be increased