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IBANDRONATE

Take ibandronate with a full glass (6 to 8 ounces) of plain water on an empty stomach. It should be taken in the morning at least 60 minutes before any food, beverage, or other medicines. Food and beverages, such as mineral water, coffee, tea, or juice, will decrease the amount of ibandronate absorbed by the body. Waiting longer than 60 minutes will allow more of the drug to be absorbed. Medicines such as antacids, calcium or vitamin supplements will also decrease the absorption of ibandronate.

Do not lie down for 60 minutes after taking ibandronate . This will help ibandronate reach your stomach faster. It will also help prevent irritation to your esophagus.

Your doctor may recommend that you eat a balanced diet with an adequate amount of calcium and vitamin D (found in milk or other dairy products). However, do not take any food, beverages, or calcium or vitamin supplements within 60 minutes or longer of taking ibandronate. To do so may keep this medicine from working properly.

Dosing

The dose of ibandronate will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of ibandronate. If your dose is different, do not change it unless your doctor tells you to do so.

• For oral dosage form (tablets):
  • For treatment of postmenopausal osteoporosis (thinning of bone)
    • Adults 2.5 mg once a day in the morning, taken at least 60 minutes before the first food, beverage, or medication. You should take ibandronate with six to eight ounces of plain water.
    • Children Use and dose must be determined by your doctor.
  • For prevention of postmenopausal osteoporosis (thinning of bone)
    • Adults 2.5 mg once a day in the morning, taken at least 60 minutes before the first food, beverage, or medication. You should take ibandronate with six to eight ounces of plain water.
    • Children Dose must be determined by your doctor.

Missed dose

If you miss a dose of this medicine, do not take it later in the day. Resume your schedule the next morning. Do not double doses.

Storage

To store this medicine:

• Keep out of the reach of children.
• Store away from heat and direct light.
• Do not store in the bathroom, near the kitchen sink, or in other damp places. heat or moisture may cause the medicine to break down.
• Keep the medicine from freezing. Do not refrigerate.
• Do not keep outdated medicine or medicine no longer needed. Ask your health care professional how you should dispose of any medicine you do not use. Be sure that any discarded medicine is out of the reach of children.

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For ibandronate, the following should be considered:

Allergies Tell your doctor if you have ever had any unusual or allergic reaction to ibandronate. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Diet Make certain your health care professional knows if you are on any special diet, such as a low-sodium or low-sugar diet. Your doctor may recommend that you eat a balanced diet with an adequate amount of calcium and vitamin D (found in milk or other dairy products).

Pregnancy Ibandronate has not been studied in pregnant women. However, studies in animals have shown that ibandronate may causes birth defects and other pregnancy problems. Before taking this medicine, make sure your doctor knows if you are pregnant or if you may become pregnant.

Breast-feeding It is not known whether ibandronate passes into breast milk. However, this medicine has been reported to pass into the milk of lactating rats.

Children Studies on this medicine have been done only in adult patients and there is no specific information comparing use of ibandronate in children with use in other age groups.

Older adults This medicine has been tested and has not been shown to cause different side effects or problems in older people than it does in younger adults.

Other medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary.

Tell your health care professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

• Hypocalcemia (low calcium levels in the blood) Must be treated first, before beginning treatment with ibandronate

• Digestion problems Taking ibandronate may be harmful to the esophagus, intestine, or stomach

• Esophagus problems or
• Intestine problems or
• Stomach problems Ibandronate may make these conditions worse

• Kidney problems The effects of ibandronate may be increased