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METHOCARBAMOL

Chlorzoxazone, metaxalone, or methocarbamol tablets may be crushed and mixed with a little food or liquid if needed to make the tablets easier to swallow.

Dosing

The dose of these medicines will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so.

For carisoprodol
• For oral dosage form (tablets):
  • For relaxing stiff, sore muscles:
    • Adults and teenagers 350 milligrams (mg) four times a day.
    • Children up to 5 years of age Dose must be determined by your doctor.
    • Children 5 to 12 years of age 6.25 mg per kilogram (2.5 mg per pound) of body weight four times a day.

For chlorphenesin
• For oral dosage form (tablets):
  • For relaxing stiff, sore muscles:
    • Adults and teenagers 800 milligrams (mg) three times a day, at first. Your doctor may decrease your dose after you begin to feel better.
    • Children Use and dose must be determined by your doctor.

For chlorzoxazone
• For oral dosage form (tablets):
  • For relaxing stiff, sore muscles:
    • Adults and teenagers 500 milligrams (mg) three or four times a day.
    • Children 125 to 500 mg three or four times a day, depending on the child's size and weight.

For metaxalone
• For oral dosage form (tablets):
  • For relaxing stiff, sore muscles:
    • Adults and teenagers 800 milligrams (mg) three or four times a day.
    • Children Use and dose must be determined by your doctor.

For methocarbamol
• For oral dosage form (tablets):
  • For relaxing stiff, sore muscles:
    • Adults and teenagers 1500 milligrams (mg) four times a day, at first. Your doctor may decrease your dose after you begin to feel better.
    • Children Use and dose must be determined by your doctor.
• For injection dosage form:
  • For relaxing stiff, sore muscles:
    • Adults and teenagers 1 to 3 grams a day, injected into a muscle or a vein. This total daily dose may be divided into smaller amounts that are given several times a day, especially when the medicine is injected into a muscle.
    • Children Use and dose must be determined by your doctor.

Missed dose

If you miss a dose of this medicine and remember within an hour or so of the missed dose, take it right away. But if you do not remember until later, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

To store this medicine:

• Keep out of the reach of children.
• Store away from heat and direct light.
• Do not store this medicine in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down.
• Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For the skeletal muscle relaxants, the following should be considered:

Allergies Tell your doctor if you have ever had any unusual or allergic reaction to any of the skeletal muscle relaxants or to carbromal, mebutamate, meprobamate (e.g., Equanil), or tybamate. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy Although skeletal muscle relaxants have not been shown to cause birth defects or other problems, studies on birth defects have not been done in pregnant women. Studies in animals with metaxalone have not shown that it causes birth defects.

Breast-feeding Carisoprodol passes into the breast milk and may cause drowsiness or stomach upset in nursing babies. It is not known whether chlorphenesin, chlorzoxazone, metaxalone, or methocarbamol passes into the breast milk. However, these medicines have not been reported to cause problems in nursing babies.

Children Studies with the skeletal muscle relaxants have been done only in adult patients, and there is no specific information comparing use of these medicines in children with use in other age groups. However, carisoprodol and chlorzoxazone have been used in children. They have not been reported to cause different side effects or problems in children than they do in adults.

Older adults Many medicines have not been tested in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information about the use of skeletal muscle relaxants in the elderly.

Other medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking a skeletal muscle relaxant, it is especially important that your health care professional know if you are taking any of the following:

• Alcohol or
• Central nervous system (CNS) depressants or
• Tricyclic antidepressants (amitriptyline [e.g., Elavil], amoxapine [e.g., Asendin], clomipramine [e.g., Anafranil], desipramine [e.g., Pertofrane], doxepin [e.g., Sinequan], imipramine [e.g., Tofranil], nortriptyline [e.g., Aventyl], protriptyline [e.g., Vivactil], trimipramine [e.g., Surmontil]) The chance of side effects may be increased

• Allergies, history of, or
• Blood disease caused by an allergy or reaction to any other medicine, history of, or
• Drug abuse or dependence, or history of, or
• Kidney disease or
• Liver disease or
• Porphyria Depending on which of the skeletal muscle relaxants you take, the chance of side effects may be increased; your doctor can choose a muscle relaxant that is less likely to cause problems

• Epilepsy Convulsions may be more likely to occur if methocarbamol is given by injection