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Medical Information
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PERMAX
(Also Known As: PERGOLIDE MESYLATE)
Additional Information
Why is this medication prescribed
Pergolide is used with another medication to treat the symptoms of Parkinson's disease (a disorder of the nervous system that causes difficulties with movement, muscle control, and balance). Pergolide is in a class of medications called dopamine agonists. It works by acting in place of dopamine, a natural substance in the brain that is needed to control movement.
Proper Use of This Medicine
If pergolide upsets your stomach, it may be taken with meals. If stomach upset continues, check with your doctor.
Dosing
The dose of pergolide will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of pergolide. If your dose is different, do not change it unless your doctor tells you to do so.
The number of tablets that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are taking pergolide.
- For oral dosage form (tablets):
- Adults: 50 micrograms a day for the first two days. The dose may be increased every three days as needed. However, the usual dose is not more than 5000 micrograms.
Missed dose
If you miss a dose of this medicine, take it as soon as you remember it. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.
Storage
To store this medicine:
- Keep out of the reach of children.
- Store away from heat and direct light.
- Do not store in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down.
- Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.
Other uses for this medicine
This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.
What other information should I know
Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your body's response to pergolide.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.
Before Using This Medicine
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For pergolide, the following should be considered:
Allergies Tell your doctor if you have ever had any unusual or allergic reaction to pergolide or other ergot medicines such as ergotamine. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.
Pregnancy Studies have not been done in pregnant women. However, pergolide has not been shown to cause birth defects or other problems in animal studies.
Breast-feeding This medicine may stop milk from being produced.
Children Studies on this medicine have been done only in adult patients, and there is no specific information about its use in children.
Older adults This medicine has been tested and has not been shown to cause different side effects or problems in older people than it does in younger adults.
Other medicines Although certain medicines should not be used together at all, in other cases 2 different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking pergolide, it is especially important that your health care professional know if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.
- Heart disease or
- Mental problems (history of) Pergolide may make the condition worse
In case of emergency overdose
In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.
Symptoms of overdose may include:
- upset stomach
- vomiting
- blurred vision
- dizziness
- fainting
- pounding heartbeat
- angry or aggressive behavior
- hallucination (seeing things or hearing voices that do not exist)
- movements that you cannot control
- tingling in arms or legs
- seizures
- fast thinking and motion

