$78.55

SABRIL

(Also Known As: VIGABATRIN)

Dosing

The dose of vigabatrin will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of vigabatrin. If your dose is different, do not change it unless your doctor tells you to do so.

• For oral dosage form ( powder):
  • For epilepsy
    • Adults To start, 1000 milligrams (mg) a day. The doctor may need to adjust the dose depending on your response to the medicine. However, the dose is usually not more than 4000 mg a day.
    • Children The dose is based on body weight and will be determined by your doctor. To start, 40 milligrams (mg) per kilogram (kg) (18.2 mg per pound) of body weight per day. Your doctor may increase your dose as needed. However, the dose is usually not more than 100 mg per kg (45.5 mg per pound) of body weight a day, taken in two smaller doses.
  • For infantile spasms
    • Children The dose is based on body weight and will be determined by your doctor. The usual dose is 50 to 100 mg per kg (22.7 to 45.5 mg per pound) of body weight per day, given in smaller doses twice a day. The doctor may need to adjust the dose based on your response to the medicine.
• For oral dosage form (tablets):
  • For epilepsy
    • Adults To start, 1000 milligrams (mg) a day. The doctor may need to adjust the dose depending on your response to the medicine. However, the dose is usually not more than 4000 mg a day.
    • Children The dose is based on body weight and will be determined by your doctor. To start, 40 mg per kg (18.2 mg per pound) of body weight a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 100 mg per kg (45.5 mg per pound) of body weight a day, taken in two smaller doses.

Missed dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

To store this medicine:

• Keep out of the reach of children.
• Store away from heat and direct light.
• Do not store in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down.
• Do not keep outdated medicine or medicine no longer needed. Ask your health care professional how you should dispose of any medicine you do not use. Be sure that any discarded medicine is out of the reach of children.

In deciding to use a medicine, the risks of taking vigabatrin must be weighed against the good it will do. This is a decision you and your doctor will make. For vigabatrin, the following should be considered:

Allergies Tell your doctor if you have ever had any unusual or allergic reaction to vigabatrin. Also tell your health care provider if you are allergic to any other substances, such as foods, preservatives, or dyes.

Pregnancy Studies have not been done in pregnant women. However, studies in rabbits have shown that vigabatrin causes birth defects. Before taking this medicine, make sure your doctor knows if you are pregnant or if you may become pregnant.

Breast-feeding It is not known if vigabatrin passes into breast milk. Because of the risk of unwanted effects in the nursing infant, breast-feeding is not recommended.

Children This medicine has been tested in children and, in effective doses, has not been shown to cause different problems than it does in adults.

Older adults Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of vigabatrin in the elderly with use in other age groups.

Other medicines Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your health care professional if you are using any other prescription or nonprescription (over-the-counter [OTC]) medicine.

• Mental illness Patients with a history of emotional or behavioral disturbances may be more likely to have an episode following vigabatrin therapy.

• Kidney disease Vigabatrin is removed from the body by the kidney; slower removal from the body may increase the chance of side effects